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Thematic Programs

Development and Disease


Information

Date

August 24, 2015 – August 26, 2015

   Official Schedule: Mon. August 24   Tue. August 25   Wed. August 26

Venue

Auditorium of the International Center for Smart Aging Research, Seiryo Campus, Tohoku University
#4 in the MAP

Summary

All of the information required to generate the intricate design of our complex brains is present in the zygote after fertilization. These genetic and epigenetic programs are carefully implemented during embryonic development, during which each cell is correctly assigned its location and function as the embryo grows. Small alterations in this seemingly impossible task sometimes occur, and can have profound consequences which may ultimately result in neurodevelopmental diseases. In the second symposium, we will discuss how the program of neural development unfolds, with the aim of understanding how errors in these processes can result in the development of brain disease.

Organizers

Yasuyuki Taki
(Professor, Graduate School of Medicine / IDAC, Tohoku University)

Tomomi Shimogori
(Team Leader, RIKEN BSI)

Poster

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Official Schedule

Mon. August 24

AM: Lab Tour/discussion

12:00 –
Registration
13:00
Welcome  Ryuta Kawashima (Dean, IDAC, Tohoku University)

Session 1: Brain Development

13:10
Francois Guillemot (The Francis Crick Institute, UK)
Signals and factors controlling stem cell activity in the adult brain
14:10
Shubha Tole (Tata Institute of Fundamental Research, India)
Early patterning of the cortical primordium
14:50
Short talk 1
(1)Takako Kikkawa (15 min)
Dmrt genes differentially participate in Cajal-Retzius cell development of the cerebral cortex
(2)Dan Ohtan Wang (15 min)
Imaging RNA in Living Neural Circuits with Hybridization-sensitive Fluorescent Probes
15:20
Break
15:40
Tomomi Shimogori (RIKEN BSI, Japan)
Input from the thalamus creates diversity of the cortical neurons
16:20
Goichi Miyoshi (@Fishell Lab, New York University, USA)
Assembly of neocortical circuitry by FoxG1, a gene associated with neurocognitive disorders
16:50
Yusuke Hirabayashi (@Polleux Lab, Columbia University, USA)
Exploring the role of the mitochondria/endoplasmic reticulum (ER) interface in axonal development
18:00
Get together@Lobby of the same building

Tue. August 25

Session 2: Brain Evolution

9:10
Wieland Huttner (Max Planck Institute, Dresden, Germany)
Neural stem and progenitor cells and neocortex expansion in development and evolution
10:10
Short talk 2
(1)Takuya Imamura (15 min)
Gene-activation-associated long non-coding RNAs for species-dependent epigenome formation
(2)Kouta Kanno (15 min)
Individual differences of courtship ultrasonic vocalizations and its neuronal correlates in male mice
10:40
Break
11:00
Erich Jarvis (Duke University Medical Center, USA)
Brain evolution of complex behavioral traits: vocal learning and spoken language
11:40
Short talk 3
(1)Asuka Matsui (15 min)
Neural activity dependent BTBD3 translocation to the cytoskeleton is essential for proper dendrite development
(2)Carina Hanashima (15 min)
Neuronal subtype specification in establishing the cerebral cortex
12:10
Lunch & Poster session

Session 3: Models for Neurodevelopmental Disease

14:00
Noboru Hiroi (Albert Einstein College of Medicine, USA)
Postnatal neurogenesis and dimensional features of autism in a genetic mouse model of 22q11.2 copy number variants
14:40
Noriko Osumi (Tohoku University, Japan)
Crosstalk between Pax6 haploinsufficiency and paternal aging in modulating offspring behavior: a possible role for epigenetic modification
15:20
Break

Session 4: Clinical Studies of Neurodevelopmental Disease

15:40
Short talk 4
Mikio Hoshino (30 min)
Analysis of autism susceptibility candidate 2 gene during development
16:10
Stephan Sanders (UCSF, USA)
Genomic architecture and gene discovery in autism spectrum disorder
16:50
Hidenori Yamasue (Tokyo University, Japan)
Crosstalk between neuroscience and clinical psychiatry with oxytocin in a neurodevelopmental disorder
17:30
Reception@Lobby of the same building

Wed. August 26

9:30
Yasuyuki Taki (Tohoku University, Japan)
Brain development using magnetic resonance imaging in healthy children
10:10
Kenji Tsuchiya (Hamamatsu Medical University, Japan)
Neurodevelopmental Trajectories of Children with Autism Spectrum Disorder
10:50
Break
11:10
Atsushi Senju (Birkbeck University of London, UK)
Development of spontaneous social cognition and autism
12:00 – 13:10
Lunch & Poster session
13:10
Yoko Kamio (National Center of Neurology and Psychiatry, Japan)
Early detection and early intervention for ASD during life course development: Not only for social-communication problems but also for diverse mental health issues
13:50
Masahiro Hirai (Jichi Medical University, Japan)
Embodied cognition from inside out in atypical development
14:30
Break
14:50
Paul Matthews (Imperial College London, UK)
Imaging in large populations: better defining later life brain disease risks in terms of development, exposure and aging
15:50
Concluding Remarks  Noriko Osumi (Tohoku University, Japan)

Event Registration

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