Redox Week in Sendai 2025

Supersulfides Biology for Life and Social Innovation

Information

Date

Thursday, April 17, 2025 – Monday, April 21, 2025

Venue

Seiryo Auditorium, School of Medicine Centennial Hall, Seiryo Campus, Tohoku University [Access]

Invited Speakers　*In order of appearance

Ken Itoh (Hirosaki University Graduate School of Medicine)
Young–Joon Surh (College of Pharmacy, Seoul National University)
Antonio Cuadrado (Autonomous University of Madrid / Servatrix Biomed S.L.)
Albena T Dinkova–Kostova (University of Dundee School of Medicine)
Masayuki Yamamoto (Tohoku University)
Yuji Naito (Kyoto Prefectural University of Medicine)
Liron Bar–Peled (Harvard Medical School)
Martin Feelisch (University of Southampton)
Koji Uchida (The University of Tokyo)
Christopher Harry Switzer (University of Leicester)
Danny Schilling (German Cancer Research Center (DKFZ))
Francisco J Corpas (Spanish National Research Council (CSIC))
Kei Wada (University of Miyazaki)
Yasuhiro Ishimaru (Tohoku University)
Ming Xian (Brown University)
Michael Pluth (University of Oregon)
Dmitry S Bilan (Russian Academy of Sciences / Pirogov Russian National Research Medical University / Federal Medical Biological Agency)
Hidehiko Nakagawa (Nagoya City University)
Kenjiro Hanaoka (Keio University)
Urara Hasegawa (Pennsylvania State University)
Jon M Fukuto (Sonoma State University)
John P. Toscano (Johns Hopkins University)
Carsten Berndt (Heinrich–Heine University Duesseldorf)
Yoshiro Saito (Tohoku University)
Ken–ichi Yamada (Kyushu University)
Uladzimir Barayeu (Tohoku University)
Takeshi Bamba (Kyushu University)
Takaaki Akaike (Tohoku University)
Tobias Peter Dick (German Cancer Research Center (DKFZ))
Philip Eaton (Queen Mary University of London)
Elias S.J. Arnér (Karolinska Institutet, Stockholm)
Marcus Conrad (Helmholtz Zentrum Műnchen / Technical University of Munich (TUM))
Jose Pedro Friedmann Angeli (University of Wűrzburg)
Eikan Mishima (Helmholtz Munich / Tohoku University)
Namgyu Lee (Dankook University)
Lloyd Trotman (Cold Spring Harbor Laboratory)
Ruma Banerjee (University of Michigan)
Péter Nagy (National Institute of Oncology / University of Veterinary Medicine / University of Debrecen)
Guenter Schwarz (University of Cologne)
Qing Cheng (Karolinska Institutet)
Mike Lange (University of California, Berkeley)
Norihisa Sugimoto (Philip Morris Japan)
Mami Noda (Xi’an Jiaotong University)
Tetsuro Ishii (University of Tsukuba)
Toru Komatsu (The University of Tokyo)
Goki Yamada (Saga University / Kagoshima University)
Taylor Alexis Covington (Harvard Medical School / Brigham and Women’s Hospital / Dana–Farber Cancer Institute)
Hirotaka Imai (Kitasato University)
Eun–Woo Lee (Korea Research Institute of Bioscience and Biotechnology (KRIBB) / University of Science and Technology (UST))
Yuta Matsuoka (Kyoto University)
Albert Van Der Vliet (University of Vermont)
Moran Benhar (Technion–Israel Institute of technology)
Tomohiro Sawa (Kumamoto University)
Sharad Kumar (University of South Australia / University of Adelaide)
Mitsuhiro Yamada (Tohoku University)
Shinji Masuda (Institute of Science Tokyo)
Tomoaki Ida (Tohoku University)
Tetsuro Matsunaga (Akita University / Tohoku University)
Tsubasa Inokuma (Tokushima University)
Aoto Kudo (Ritsumeikan University)
Fan–Yan Wei (Tohoku University)
Motohiro Nishida (Kyushu University / National Institutes of Natural Sciences / SOKENDAI)
Ryo Ushioda (Kyoto Sangyo University)
Fumito Ichinose (Massachusetts General Hospital / Harvard Medical School)
Masuko Ushio–Fukai (Augusta University)
Shohei Murakami (Tohoku University)
Akiyuki Nishimura (National Institute for Physiological Sciences)
Isshin Shiiba (Gakushuin University)
Shunichi Tayama (Tohoku University)
Simran M. Gupta (Indian Institute of Science Education and Research)
Edward E Schmidt (University of Veterinary Medicine Budapest / Montana State University)
Rakesh P Patel (University of Alabama at Birmingham)
Paraskevi Kritsiligkou (The University of Liverpool)
Huaiwei Liu (Shandong University)
Hiroaki Fujita (Kyoto University)
Yosuke Funato (Kyoto University)
Meg Shieh (Brown University)
Yusuke Hirata (Tohoku University)
Mayumi Ikeda–Imafuku (Wakayama Medical University)
Haruna Takeda (Dana–Farber Cancer Institute)
Melanie Madhani (University of Birmingham)
Miriam M Cortese–Krott (Heinrich–Heine–University of Dűsseldorf)
Tohru Fukai (Augusta University / Charlie Norwood Veterans Affairs Medical Center)
David Jospeh Lefer (Cedars–Sinai Medical Center)
Takakazu Nakabayashi (Tohoku University)
Yoshiaki Furukawa (Keio University)
Atsushi Tahara (Tohoku University)
Wei Han (Kyushu University)
Sernur Sena Yildiz (Max Planck Institute for Polymer Research)
Shingo Kasamatsu (Osaka Metropolitan University)
Ethan James York (University of Leicester)
Hozumi Motohashi (Tohoku University)
Chiaki Takahashi (Kanazawa University)
Thales Papagiannakopoulos (NYU School of Medicine)
Douglas D Thomas (University of Illinois Chicago)
Nobuaki Takahashi (Kyoto University)

Time Schedule

Thursday, April 17, 2025
08:50 – 09:00: Opening Remarks; Hozumi Motohashi (Department of Medical Biochemistry, Tohoku University Graduate School of Medicine)

Session 1: 30th Anniversary of NRF2: Pioneering the Path Forward
Chairperson: Hozumi Motohashi (Tohoku University)
09:00 – 09:25: Ken Itoh (Hirosaki University); Keap1–Nrf2, mitochondrial stress, and aging: Adapting to environmental challenges

09:25 – 09:50: Young–Joon Surh (Seoul National University); NRF2 and STAT3 alliance accelerates breast cancer growth and progression

09:50 – 10:15: Antonio Cuadrado (Autonomous University of Madrid / Servatrix Biomed S.L.); Targeting NRF2 for therapy in neurodegeneration and in liver fibrosis

10:15 – 10:40: Albena T Dinkova–Kostova (University of Dundee); Regulation of KEAP1/NRF2 by electrophiles and protein–protein interaction inhibitors

10:40 – 11:15: Masayuki Yamamoto (Tohoku University); The KEAP1–NRF2 pathway: From molecular stress sensors to human disease

Lunch Seminar (Sponsored by: SHIMADZU CORPORATION)
Chairperson: Takaaki Akaike (Tohoku University)
11:20 – 12:05: Yuji Naito (Kyoto Prefectural University of Medicine); Insights into the microbiota–gut–brain axis from longevity research

Session 2: Sulfur and oxygen redox biology and medicine
Chairpersons: Christopher Harry Switzer (University of Leicester), Martin Feelisch (University of Southampton)
12:10 – 12:35: Liron Bar–Peled (Harvard Medical School); Identification of druggable and redox vulnerabilities in cancer

12:35 – 13:00: Martin Feelisch (University of Southampton); Sulfur metabolism at high altitude

13:00 – 13:25: Koji Uchida (The University of Tokyo); Lysine N–pyrrolation is a carbonyl–derived protein modification associated with autoimmune diseases

13:25 – 13:50: Christopher Harry Switzer (University of Leicester); Reactive sulfur species in hypoxia: Chemistry, signalling and metabolism

13:50 – 14:10: Danny Schilling (German Cancer Research Center (DKFZ)); Exploring the regulation and function of protein persulfidation with a new quantitative assay

Session 3: NO and supersulfide in prokaryotes and plants
Chairperson: Tetsuro Matsunaga (Akita University / Tohoku University)
14:15 – 14:40: Francisco J Corpas (Spanish National Research Council (CSIC)); Physiological nitro–oxidative stress during the ripening of pepper fruit: Implication of NO and H₂S

14:40 – 15:05: Kei Wada (University of Miyazaki); Structural and functional analyses of the SUF protein complex involved in de novo iron–sulfur cluster biosynthesis

15:05 – 15:25: Yasuhiro Ishimaru (Tohoku University); Supersulfide in photosynthetic organisms

Session 4: Supersulfide probe development and imaging
Chairpersons: Ming Xian (Brown University), Hidehiko Nakagawa (Nagoya City University)
15:30 – 15:55: Ming Xian (Brown University); Chemical tools for regulating reactive sulfur species

15:55 – 16:20: Michael Pluth (University of Oregon); Chemical tools and models for investigating reactive sulfur and selenium species

16:20 – 16:45: Dmitry S Bilan (Russian Academy of Sciences / Pirogov Russian National Research Medical University / Federal Medical Biological Agency); Genetically encoded fluorescent biosensor Persic for per–/polysulfides registration

16:45 – 17:10: Hidehiko Nakagawa (Nagoya City University); Photocontrolled transfer of sulfane sulfur with caged compounds

17:10 – 17:35: Kenjiro Hanaoka (Keio University); Development of fluorogenic probes for supersulfide and H2S and their application to inhibitor screening

17:35 – 17:55: Urara Hasegawa (Pennsylvania State University); Polymeric material approaches for controlled delivery of bioactive sulfur species

19:00 –: Welcome Reception @Westin Sendai

Friday, April 18, 2025
Session 5: Redox biology of chalcogens and lipid peroxidation
Chairpersons: John P. Toscano (Johns Hopkins University), Yoshiro Saito (Tohoku University)
08:40 – 09:05: Jon M Fukuto (Sonoma State University); Chemical rationale for the biological properties and utility of polysulfur species

09:05 – 09:30: John P. Toscano (Johns Hopkins University); Hydropersulfides attenuate doxorubicin–induced cardiotoxicity while boosting its anticancer action: Exploring the role of cellular redox homeostasis

09:30 – 09:55: Carsten Berndt (Heinrich–Heine University Duesseldorf); Glutaredoxin–dependent differentiation and survival in the brain

09:55 – 10:20: Yoshiro Saito (Tohoku University); Redox regulation triad: Molecular interactions of selenium, supersulfide, and iron

10:20 – 10:45: Ken–ichi Yamada (Kyushu University); Lysosomal lipid peroxidation triggers ferroptosis induction

10:45 – 11:10: Uladzimir Barayeu (Tohoku University); Evolutionarily conserved cyclo–octasulfur prevents ferroptosis in mammals

Opening Ceremony: Center for Supersulfide Research
11:10 – 12:00: Remarks from Distinguished Guests
Mizue Shiomi (Director–General, Research Promotion Bureau, MEXT)
Teiji Tominaga (President, Tohoku University)
Naoto Ishii (Dean, Tohoku University Graduate School of Medicine)
Yasunori Yamamoto (President, Shimadzu Corporation)

Lunch Seminar (Sponsored by: JAPAN BIOSCIENCES CO., LTD.)
Chairperson: Fan–Yan Wei (Tohoku University)
12:10 – 12:55: Takeshi Bamba (Kyushu University); Development of next generation metabolomics technologies

Memorial Joint Symposium: University for International Research Excellence, Center for Supersulfide Research & MEXT / JSPS Research Projects: G–ReXS & Transformation Research Area
Chairperson: Hozumi Motohashi (Tohoku University)
13:10 – 13:20: Remarks from Distinguished Guest
Tsuyoshi Sugino (President, Japan Society for the Promotion of Science)

Keynote
13:20 – 14:00: Takaaki Akaike (Tohoku University); Redox signal regulation by chalcogen supermolecules

Keynote
14:00 – 14:30: Tobias Peter Dick (German Cancer Research Center (DKFZ)); Understanding thiol–based redox switches: Where do we stand?

14:30 – 14:55: Philip Eaton (Queen Mary University of London); Redox sensing and signaling in the cardiovascular system

14:55 – 15:20: Elias S.J. Arnér (Karolinska Institutet, Stockholm); Probing and targeting the selenoprotein thioredoxin reductase 1 (TXNRD1) for modulated redox control of cell function

Plenary Lecture
Chairperson: Hozumi Motohashi (Tohoku University)
15:25 – 16:10: Marcus Conrad (Helmholtz Zentrum Műnchen / Technical University of Munich (TUM)); Ferroptosis as a pharmacologically tractable form of cell death to prevent neurodegenerative disease

Session 6: Ferroptosis in chalcogen biology
Chairpersons: Ken–ichi Yamada (Kyushu University), Eikan Mishima (Helmholtz Munich / Tohoku University)
16:20 – 16:45: Jose Pedro Friedmann Angeli (University of Wűrzburg); Unraveling selenium metabolism: Novel pathways and transport mechanisms

16:45 – 17:10: Eikan Mishima (Helmholtz Munich / Tohoku University); PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization

17:10 – 17:35: Namgyu Lee (Dankook University); The paradox of selenium in ferroptosis regulation

17:35 – 18:00: Lloyd Trotman (Cold Spring Harbor Laboratory); Triaptosis – Oxidative cell death and cancer therapy

19:00 –: Banquet (for invited only) @Westin Sendai

Saturday, April 19, 2025
Session 7: Sulfide and supersulfides biosyntheses and metabolisms
Chairpersons: Péter Nagy (National Institute of Oncology / University of Veterinary Medicine / University of Debrecen), Guenter Schwarz (University of Cologne)
08:40 – 09:10: Ruma Banerjee (University of Michigan); Sulfide signaling: From biomolecules to behavior

09:10 – 09:35: Péter Nagy (National Institute of Oncology / University of Veterinary Medicine / University of Debrecen); Realigned sulfur metabolism is crucial in BRAF V600E–targeted therapy resistance in melanoma

09:35 – 10:00: Guenter Schwarz (University of Cologne); Sulfite oxidase deficiency protects from ROS by S–sulfocysteine–dependent GSH synthesis

10:00 – 10:20: Qing Cheng (Karolinska Institutet); Redefining the genetic code enables recombinant selenoprotein expression in engineered E. coli strains, including a fully synthetic variant

10:20 – 10:40: Mike Lange (University of California, Berkeley); Lipid droplet quality control: Ferroptosis Suppressor Protein 1 protects stored neutral lipids from oxidative damage

Session 8: Roundtable
10:45 – 11:45: Sulfide Terminology; Chairpersons:
Uladzimir Barayeu (Max Planck Institute for Polymer Research)
Tobias Peter Dick (German Cancer Research Center (DKFZ))
Panelist:
Takaaki Akaike (Tohoku University)
Uladzimir Barayeu (Max Planck Institute for Polymer Research)
Tobias Peter Dick (German Cancer Research Center (DKFZ))
Christopher Harry Switzer (University of Leicester)

Lunch Seminar (Sponsored by: Philip Morris Japan Ltd.)
Chairperson: Motohiro Nishida (Kyushu University)
11:50 – 12:35: Norihisa Sugimoto (Philip Morris Japan); Designing a smoke–free future: Evidence supporting the Tobacco Heating System by PMI; Mami Noda (Xi’an Jiaotong University); Reconsidering “nicotine” from a pathophysiological perspective

Oral Session 1
Chairperson: Takashi Toyama (Tohoku University)
12:45 – 13:00: Tetsuro Ishii (University of Tsukuba); Glutathione sensor neutral sphingomyelinase 2–dependent activation of transcription factor NRF2 via ceramide/ PKCζ /casein kinase 2 axis

13:00 – 13:15: Toru Komatsu (The University of Tokyo); Single–molecule protein functional analysis for understanding pathological protein activities at proteoform levels

13:15 – 13:30: Goki Yamada (Saga University / Kagoshima University); Endoplasmic reticulum–associated degradation system mediator, selenoprotein S/K can control the cellular localization of NF–E2–p45 related factor

13:30 – 13:45: Taylor Alexis Covington (Harvard Medical School / Brigham and Women’s Hospital / Dana–Farber Cancer Institute); Effects of in utero oxidative stress and redox regulation in cardiac development

13:45 – 14:35: Poster Session [PDF]

Oral Session 2
Chairperson: Eikan Mishima (Helmholtz Munchen / Tohoku University)
14:35 – 14:50: Hirotaka Imai (Kitasato University); Phenotype analysis of cartilage–specific GPx4 KO mice and mutation of metaphyseal dysplasia patients

14:50 – 15:05: Eun–Woo Lee (Korea Research Institute of Bioscience and Biotechnology (KRIBB) / University of Science and Technology (UST)); Methionine metabolism links with phospholipid and glutamine metabolism to drive ferroptosis

15:05 – 15:20: Yuta Matsuoka (Kyoto University); Breath biomarkers for monitoring lipid peroxidation and ferroptosis in vivo

Session 9: Redox signaling in inflammation and aging
Chairpersons: Albert Van Der Vliet (University of Vermont), Tomohiro Sawa (Kumamoto University)
15:25 – 15:50: Albert Van Der Vliet (University of Vermont); Bromine: A critical element in oxidative extracellular matrix remodeling in health and disease

15:50 – 16:15: Moran Benhar (Technion–Israel Institute of technology); Mechanistic insights into reactive sulfur species mediated protection from inflammatory cell death

16:15 – 16:40: Tomohiro Sawa (Kumamoto University); Regulation of innate immune and inflammatory responses by supersulfides

16:40 – 17:05: Sharad Kumar (University of South Australia / University of Adelaide); Caspase–2 in oxidative stress, ageing and cancer

17:05 – 17:30: Mitsuhiro Yamada (Tohoku University); Roles of supersulfides in airway inflammation and T–cell activation

Oral Session 3
Chairperson: Masanobu Morita (Tohoku University)
17:35 – 17:50: Shinji Masuda (Institute of Science Tokyo); Heme bound to the bacterial transcription factor SqrR / YgaV catalyzes the oxygen–dependent conversion of H₂S to supersulfide to control gene expression

17:50 – 18:05: Tomoaki Ida (Tohoku University); Sulfane sulfur of glutathione trisulfide (GSSSG) is incorporated into cells

18:05 – 18:20: Tetsuro Matsunaga (Akita University / Tohoku University); Cyclo–octa–sulfur facilitates energy metabolism in mitochondria

18:20 – 18:35: Tsubasa Inokuma (Tokushima University); Development of novel sulfur reagents for the controlled chemical synthesis of supersulfides

18:35 – 18:50: Aoto Kudo (Ritsumeikan University); Cysteine persulfidation in the rhodanese–like sulfurtransferase ExtH from Geobacter sulfurreducens PCA

Sunday, April 20, 2025
Session 10: Mitochondria and inter–organellar redox biology (IDAC session)
Chairpersons: Fan–Yan Wei (Tohoku University), Fumito Ichinose (Massachusetts General Hospital / Harvard Medical School)
08:40 – 09:05: Fan–Yan Wei (Tohoku University); Mitochondrial radical stress signature and aging

09:05 – 09:30: Motohiro Nishida (Kyushu University / National Institutes of Natural Sciences / SOKENDAI); Supersulfide–mediated mitochondria quality control and cardiac stress resistance

09:30 – 09:55: Ryo Ushioda (Kyoto Sangyo University); Redox–mediated maintenance of endoplasmic reticulum homeostasis

09:55 – 10:20: Fumito Ichinose (Massachusetts General Hospital / Harvard Medical School); Role of hypoxia and sulfur metabolism in mitochondrial diseases

10:20 – 10:45: Masuko Ushio–Fukai (Augusta University); Integrating redox signaling, mitochondrial dynamics and cell metabolism: Drivers of angiogenesis in peripheral arterial disease

Oral Session 4
Chairperson: Hiroki Sekine (Tohoku University)
10:50 – 11:05: Shohei Murakami (Tohoku University); Supersulfide synthesis in mitochondria is essential for mitochondrially–encoded protein expression

11:05 – 11:20: Akiyuki Nishimura (National Institute for Physiological Sciences); Supersulfide–based redox modification of Drp1 has critical role in cardiac stress tolerance and mitochondrial quality control

11:20 – 11:35: Isshin Shiiba (Gakushuin University); New roles of organelle-mitochondria contacts

11:35 – 11:50: Shunichi Tayama (Tohoku University); Supersulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation

11:50 – 12:05: Simran M. Gupta (Indian Institute of Science Education and Research); Biocatalytic generation of persulfides and hydrogen sulfide for modulating antioxidant and anti–inflammatory responses

12:05 – 12:55: Public Lecture (in Japanese); Yoshiro Saito (Tohoku University)

Session 11: Thiol and chalcogen biology in redox medicine
Chairpersons: Rakesh P Patel (University of Alabama at Birmingham), Edward E Schmidt (University of Veterinary Medicine Budapest / Montana State University)
12:55 – 13:20: Edward E Schmidt (University of Veterinary Medicine Budapest / Montana State University); Cystine C–S bond cleavage fuels cysteine production under disulfide reductase deficiency

13:20 – 13:45: Rakesh P Patel (University of Alabama at Birmingham); Hydrogen peroxide increases red blood cell surface high mannose N–glycans; Mechanistic insights and functional implications

13:45 – 14:10: Paraskevi Kritsiligkou (The University of Liverpool); Utilising tethered biosensors to uncover redox heterogeneity

14:10 – 14:35: Huaiwei Liu (Shandong University); Polysulfides mediate multiple types of protein modification and benefits tumor growth

14:35 – 14:55: Hiroaki Fujita (Kyoto University); Genome–wide iron–induced ferroptosis screen uncovers PRDX6 as a novel selenium carrier protein

14:55 – 15:15: Yosuke Funato (Kyoto University); Regulation of signal transduction by diverse chemical modifications via reactive sulfur species

15:15 – 15:45: Poster Session [PDF]

Rising Star Session
Chairperson: Tomohiro Sawa (Kumamoto University)
15:45 – 16:05: Meg Shieh (Brown University); Understanding polysulfide–mediated papain inhibition and differentiating between disulfide vs persulfide formation

16:05 – 16:25: Yusuke Hirata (Tohoku University); Mitochondrial targeting by conjugated fatty acids drives ferroptosis

16:25 – 16:45: Mayumi Ikeda–Imafuku (Wakayama Medical University); Supersulfide–modulated antioxidative activity of human serum albumin: A novel approach for acute kidney injury treatment

16:45 – 17:05: Haruna Takeda (Dana–Farber Cancer Institute); OxiT: A comprehensive stoichiometric landscape of cysteine oxidation during T cell activation

Session 12: Supersulfide in cardiovascular disease regulation
Chairpersons: Melanie Madhani (University of Birmingham), Adrian Hobbs (Queen Mary University of London)
17:10 – 17:35: Melanie Madhani (University of Birmingham); Manipulating persulfides in cardiovascular health and disease from bench to bedside

17:35 – 18:00: Miriam M Cortese–Krott (Heinrich–Heine–University of Düsseldorf); The role of endothelial and red blood cell eNOS in renal function and blood pressure regulation

18:00 – 18:25: Tohru Fukai (Augusta University / Charlie Norwood Veterans Affairs Medical Center); Interplay between ROS, endothelial metabolism, and copper transport protein in vascular inflammatory disease

18:25 – 18:50: David Jospeh Lefer (Cedars–Sinai Medical Center); Hydrogen sulfide therapy for cardiometabolic heart failure

19:30 –: Get–together @Kokubuncho “Back Page Bar”

Monday, April 21, 2025
Oral Session 5
Chairperson: Yusuke Hirata (Tohoku University)
08:40 – 08:55: Takakazu Nakabayashi (Tohoku University); Label–free observation of supersulfides and their metabolic reactions in a single cell using Raman imaging

08:55 – 09:10: Yoshiaki Furukawa (Keio University); Critical roles of cysteine residues in misfolding of Cu/Zn–superoxide dismutase associated with neurodegenerative diseases

09:10 – 09:25: Atsushi Tahara (Tohoku University); Interdisciplinary sciences leading to utilization of carbon resources by using organosulfur compounds

09:25 – 09:40: Wei Han (Kyushu University); Design, synthesis, and biological activity of organosulfur / selenium compounds

09:40 – 09:55: Sernur Sena Yildiz (Max Planck Institute for Polymer Research); Regulation of cysteine persulfide incorporation by CARS and its impact on protein synthesis

09:55 – 10:10: Shingo Kasamatsu (Osaka Metropolitan University); Analysis of metabolic dynamics of supersulfides in hibernating golden hamsters

10:10 – 10:25: Ethan James York (University of Leicester); Exploring the role of supersulfides in tumour hypoxia

Session 13: Redox biology in cancer and chemotherapeutics
Chairpersons: Thales Papagiannakopoulos (NYU School of Medicine), Douglas D Thomas (University of Illinois Chicago)
10:35 – 11:00: Hozumi Motohashi (Tohoku University); Supersulfides and cancer malignancy

11:00 – 11:25: Chiaki Takahashi (Kanazawa University); KRAS–LKB1–KEAP1 mutation in NSCLC confers resistance to KRAS inhibitor through enhanced anaplerosis

11:25 – 11:50: Thales Papagiannakopoulos (NYU School of Medicine); Redox mechanisms of lung cancer progression

11:50 – 12:15: Douglas D Thomas (University of Illinois Chicago); Nitric oxide is a master regulator of the cellular methylome by inhibiting ten–eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome

12:15 – 12:40: Nobuaki Takahashi (Kyoto University); Oxidative stress defense in cancer

12:40 –: Closing Remarks; Fan–Yan Wei (IDAC, Tohoku University)

Organizing Committee

Takaaki Akaike (Tohoku University Graduate School of Medicine)
Hozumi Motohashi (Tohoku University Graduate School of Medicine)
Motohiro Nishida (Kyushu University Graduate School of Pharmaceutical Sciences)
Yoshiro Saito (Tohoku University Graduate School of Pharmaceutical Sciences)
Fan–Yan Wei (Institute of Development, Aging and Cancer, Tohoku University)
Tomohiro Sawa (Faculty of Life Sciences, Kumamoto University)

Supported by

Center for Environmental Response and Aging (CERA), Tohoku University
Great Britain Sasakawa Foundation
Institute of Development, Aging and Cancer (IDAC), Tohoku University
Japanese Biochemical Society (JBS)
Japan Society for the Promotion of Science (JSPS)
Japan Society for Redox Supermolecule Biology & Exploratory Medicine (JReXBEM)
— former Nitric Oxide Society of Japan (NOSJ)
Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
Nitric Oxide Society
Sendai Tourism, Convention and International Association (SenTIA)
Tohoku Forum of Creativity (TFC), Future Society Design Program, Tohoku University

Contact

Email: redoxweek2025*senkyo.co.jp (change * to @)

Future Society Design Program