Thematic Programs

Aging Biology: Understanding Aging on a Molecular Level


Information

The goal of the conference is to understand the molecular mechanisms of aging at the cellular and organismal levels, and to let young investigators share and discuss cutting edge science in the field of aging biology. Through this discussion, we will propose a prescription for a healthier lifestyle by regulating aging processes and aging-related diseases.

Date

May 10, 2017 – May 12, 2017

Venue

International Conference Room
Smart Aging International Research Center, Institute of Development, Aging and Cancer, Tohoku University
Access

Invited Speakers  [Nov. 13, 2017 Updated]

Keith Blackwell (Joslin Diabetes Center and Harvard Medical School)
Vilhelm A. Bohr (National Institute of Aging, NIH)
Judith Campisi (Buck Institute for Research on Aging)
Jan M. van Deursen (Mayo Clinic)
Eiji Hara (Osaka University)
Hisanori Horiuchi (IDAC, Tohoku University)
Shin-ichiro Imai (Washington University School of Medicine)
Fuyuki Ishikawa (Kyoto University)
Jan Hoeijmakers (Erasmus MC Rotterdam)
Hideki Katagiri (Tohoku University)
Elsa Logarinho (University of Porto)
Tom Misteli (National Cancer Institute, NIH)
Hozumi Motohashi (IDAC, Tohoku University)
Yo-ichi Nabeshima (Foundation for Biomedical Research and Innovation)
Makoto Nakanishi (University of Tokyo)
Yasuhisa Matsui (IDAC, Tohoku University)
Masashi Narita (University of Cambridge)
Emi Nishimura (Tokyo Medical and Dental University)
Toshihiko Ogura (IDAC, Tohoku University)
Yasufumi Sato (IDAC, Tohoku University)
Luis J. Sigal (Thomas Jefferson University)
Toshiyuki Takai (IDAC, Tohoku University)
Keiyo Takubo (Research Institute, National Center for Global Health and Medicine)
Kozo Tanaka (IDAC, Tohoku University)
Amy Wagers (Joslin Diabetes Center and Harvard Medical School)
Akira Yasui (IDAC, Tohoku University)

Time Schedule  [Nov. 13, 2017 Updated]

・Special website in IDAC

Wednesday, May 10, 2017
Stress response and genome integrity
8:50 – 9:00
Opening
Sadayoshi Ito (Director of TFC, Tohoku University)
Kozo Tanaka (IDAC, Tohoku University)
Session 1: Mechanisms of Aging
Chair: Kozo Tanaka (IDAC, Tohoku University)
9:00 – 9:40
Yo-ichi Nabeshima (Foundation for Biomedical Research and Innovation)
Alpha-Klotho in health and diseases
9:40 – 10:20
Tom Misteli (National Cancer Institute, NIH)
Nuclear architecture and aging
10:20 – 10:40
Coffee Break
Session 2: Stress Response and Aging
Chair: Yasufumi Sato (IDAC, Tohoku University)
10:40 – 11:20
Hozumi Motohashi (IDAC, Tohoku University)
Regulation of NRF2 activity for anti-inflammation and stem cell Maintenance
11:20 – 12:00
Keith Blackwell (Joslin Diabetes Center and Harvard Medical School)
Two faces of C. elegans SKN-1 and what they tell us about Nrf1 and Nrf2
12:00 – 14:00
Lunch
Session 3: Interventions in Aging
Chair: Hozumi Motohashi (IDAC, Tohoku University)
14:00 – 14:40
Shin-ichiro Imai (Washington University School of Medicine)
Achieving Productive Aging: The Systemic Regulatory Mechanism of Mammalian Aging and Longevity and Anti-Aging Intervention
14:40 – 15:20
Masashi Narita (University of Cambridge)
Cell-cell communication in senescence
15:20 – 16:00
Jan M. van Deursen (Mayo Clinic)
Delaying Aging and Disease by Senolysis
16:00 – 16:20
Coffee Break
Session 4: Genomic Instability in Aging
Chair: Natsuko Chiba (IDAC, Tohoku University)
16:20 – 17:00
Akira Yasui (IDAC, Tohoku University)
Chromatin remodeling, DNA repair and transcriptional regulation in cancer and cellular aging
17:00 – 17:40
Vilhelm A. Bohr (National Institute of Aging, NIH)
DNA damage, neurodegeneration and mitochondrial dysfunction
17:40 – 18:20
Jan Hoeijmakers (Erasmus MC Rotterdam)
DNA damage, impact on aging, neurodegeneration and the effect of nutritional interventions
Thursday, May 11, 2017
Cell senescence and aging process of tissues
Session 5: Cellular Senescence (1)
Chair: Hideki Katagiri (Tohoku University)
9:00 – 9:40
Makoto Nakanishi (University of Tokyo)
Mechanisms of senescence induction and maintenance and their role in aging
9:40 – 10:20
Fuyuki Ishikawa (Kyoto University)
Cellular senescence in Post-mitotic cells
10:20 – 10:40
Coffee Break
Session 6: Cellular Senescence (2)
Chair: Toshihiko Ogura (IDAC, Tohoku University)
10:40 – 11:20
Eiji Hara (Osaka University)
The roles and mechanisms of cellular senescence in aging and cancer
11:20 – 12:00
Judith Campisi (Buck Institute for Research on Aging)
Cellular senescence and aging phenotypes: Yin and yang
Lunch & Poster Viewing
12:00 –
Travel cost reimbursement time only for overseas speakers
12:00 – 13:00
Discussion with poster presentators
13:00 –
Tour to ToMMO for domestic speakers
14:00 –
Tour to ToMMO for overseas speakers
Session 7: Stem Cells and Aging
Chair: Yasuhisa Matsui (IDAC, Tohoku University)
15:00 – 15:40
Emi Nishimura (Tokyo Medical and Dental University)
Stem cell aging: The core to orchestrates tissue aging
15:40 – 16:20
Keiyo Takubo (Research Institute, National Center for Global Health and Medicine)
Transcriptional program for hematopoietic stem cell aging
16:20 – 17:00
Amy Wagers (Joslin Diabetes Center and Harvard Medical School)
Local and systemic regulators of aging muscle stem cells
17:00 – 17:20
Coffee Break
Session 8: Immune System and Aging
Chair: Koetsu Ogasawara (IDAC, Tohoku University)
17:20 – 18:00
Toshiyuki Takai (IDAC, Tohoku University)
Immunoreceptors Regulating Autoantibody Production in Ageing
18:00 – 18:40
Luis J. Sigal (Thomas Jefferson University)
NK cells in Aging
18:50 –
Group Photo
Friday, May 12, 2017
Session 9: Chromosomal Changes in Aging
Chair: Hisanori Horiuchi (IDAC, Tohoku University)
9:00 – 9:40
Kozo Tanaka (IDAC, Tohoku University)
Chromosomal instability in aging and cancer
9:40 – 10:20
Elsa Logarinho (University of Porto)
Getting older from an old mitosis
10:20 – 10:40
Coffee Break
Session 10: Organismal Aging
Chair: Toshiyuki Takai (IDAC, Tohoku University)
10:40 – 11:20
Yasufumi Sato (IDAC, Tohoku University)
Novel link between the regulation of angiogenesis and healthy longevity
11:20 – 12:00
Hisanori Horiuchi (IDAC, Tohoku University)
A novel functional mechanism of metformin, a hypoglycemic drug with life-span extension potential
12:15 – 13:45
Lunch & Meet The Experts
Session 11: Aging-related Disorders
Chair: Akira Yasui (IDAC, Tohoku University)
14:00 – 14:40
Yasuhisa Matsui (IDAC, Tohoku University)
Molecular bases of germ cell properties ensuring continuity of lives
14:40 – 15:20
Toshihiko Ogura (IDAC, Tohoku University)
A possibility of aging control – an approach from mechanobiology
15:20 – 16:00
Hideki Katagiri (Tohoku University)
Neuronal Information Highways for Systemic Regulation of Glucose and Energy Metabolism
16:00 –
Closing Koetsu Ogasawara (IDAC, Tohoku University)

Poster

Aging Biology: Download [PDF]

Event Registration

Closed

Contact

Registration inquiries for “Aging Science: from molecules to Society”, please contact:
Ms. Motoko Konno
Email: motoko.konno.a4*tohoku.ac.jp (Change * to @)