International Symposium 1: in conjunction with International Nitric Oxide Meeting
Information
Date
Saturday, October 29, 2022 – Sunday, October 30, 2022
Venue
Hybrid: Campus Map of Seiryo Campus
- Seiryo Auditorium: School of Medicine Centennial Hall, Seiryo Campus, Tohoku University [Access]
- Medical Megabank: Tohoku Medical Megabank Building, Seiryo Campus, Tohoku University [Access]
- IDAC: Institute of Development, Aging and Cancer, Seiryo Campus, Tohoku University [Access]
- Gonryo Hall: Gonryo Hall, Seiryo Campus, Tohoku University [Access]
Invited Speakers
Amrita Ahluwalia (Queen Mary University of London)
Mabruka Alfaidi (LSU Health Shreveport)
Lucas R. Carvalho (Karolinska Institutet)
Miriam M. Cortese–Krott (University of Düsseldorf)
Brian Cunniff (University of Vermont Cancer Center)
Anthony William Demartino (University of Maryland School of Medicine)
Gina M. Denicola (Moffitt Cancer Center)
Philip Eaton (Queen Mary University of London)
Juan Bernardo Ochoa Gautier (Medical Director ICU – Hunterdon Medical Center)
Christopher M. Hine (Cleveland Clinic Lerner Research Institute)
Sophia Katharina Heuser (Heinrich–Heine–University)
Yvonne Janssen–Heininger (University of Vermont)
Jon O. Lundberg (Karolinska Institute)
Melanie Madhani (University of Birmingham)
Atsushi Matsuzawa (Tohoku University)
Hiroaki Miki (Osaka University)
Claudia R. Morris (Emory University)
Hozumi Motohashi (Tohoku University)
Péter Nagy (National Institute of Oncology)
Motohiro Nishida (Kyushu University)
Tadahisa Numakura (Tohoku University)
Augusto C. Ochoa (LSU–LCMC Cancer Center, NEW ORLEANS, School of Medicine)
Richard Onalo (University of Abuja)
Yasuhito Onodera (Hokkaido University)
Thales Papagiannakopoulos (NYU Grossman School of Medicine)
Erika L. Pearce (Johns Hopkins University)
John Pernow (Karolinska Institutet)
Tejaswini Parlapalle Reddy (Houston Methodist Research Institute)
Gaetano Santulli (Albert Einstein College of Medicine)
Tomohiro Sawa (Kumamoto University)
Sruti Shiva (University of Pittsburgh)
Adam Carl Straub (University of Pittsburgh)
Christopher Switzer (Queen Mary University of London)
Douglas D. Thomas (University of Illinois Chicago)
Masato Tsutsui (University of the Ryukyus)
Yasuteru Urano (The University of Tokyo)
David Anderson Wink (National Cancer Institute)
Hasan Zaki (The University of Texas Southwestern Medical Center)
Time Schedule [Oct. 28, 2022 Updated]
* Please click to open details
Seiryo Auditorium
- Saturday, October 29, 2022
- Session N1: NO and Supersulfide in Cardiovascular Regulation
- Chairpersons:
Motohiro Nishida (Kyushu University / National Institute for Physiological Sciences)
Philip Eaton (Queen Mary University of London) - 10:00 – 10:40
- Amrita Ahluwalia (Queen Mary University of London)
- Accelerating inflammatory resolution to improve endothelial function and vascular health: Targeting the non–canonical pathway for NO
- 10:40 – 11:10
- Masato Tsutsui (University of the Ryukyus)
- Diverse pathogenetic roles of the NOS system: Lessons from triple NOSs null mice
- 11:10 – 11:40
- Motohiro Nishida (Kyushu University)
- Cardiac ischemic stress resistance regulated by supersulfide
- 11:40 – 12:00
- Melanie Madhani (University of Birmingham)
- Nitrite and persulfide lowers blood pressure
- Plenary Lecture
- Chairperson: Takaaki Akaike (Tohoku Univeristy)
- 13:00 – 13:45
- Philip Eaton (Queen Mary University of London)
- Oxidant–induced vasodilation – Mechanisms and therapeutic opportunities
- Sunday, October 30, 2022
- Plenary Lecture
- Chairperson: Hozumi Motohashi (Tohoku University)
- 09:00 – 09:45
- Erika L. Pearce (Johns Hopkins University) [Online]
- Pain and sulfuring in the immune response: Translating what we learned from slime mold to T cells
- Session N11: Nitrite Biology II
- Chairpersons:
Martin Feelisch (University of Southampton)
Miriam M. Cortese–Krott (Heinrich Heine University Düsseldorf) - 10:00 – 10:30
- Sruti Shiva (University of Pittsburgh)
- Nitrite regulates normoxic mitochondrial dynamics and function to confer cardiovascular protection
- 10:30 – 11:00
- Miriam M. Cortese–Krott (University of Düsseldorf)
- The role of red blood cells in regulation of vascular tone and blood pressure
- 11:00 – 11:30
- John Pernow (Karolinska Institutet) [Online]
- The role of nitric oxide signaling in red blood cells in cardiac ischemia–reperfusion
- 11:30 – 12:00
- Jon O. Lundberg (Karolinska Institute) [Online]
- Generation of dinitrosyl iron complexes by the gut microbiota
- Plenary Lecture
- Chairperson: Tomohiro Sawa (Kumamoto University)
- 13:00 – 13:45
- Yasuteru Urano (The University of Tokyo)
- Chemical medicine: New cancer medical technology based on live fluorescence imaging
- Session N7: NO and Sulfur Metabolism in Cancer
- Chairpersons:
Hozumi Motohashi (Tohoku University)
Thales Papagiannakopoulos (NYU Grossman School of Medicine) - 15:30 – 15:45
- Hozumi Motohashi (Tohoku University)
- NRF2 addiction and sulfur metabolism in cancer cells
- 15:45 – 16:12
- Gina M. Denicola (Moffitt Cancer Center) [Online]
- In vivo stable isotope tracing in genetically engineered cancer models to evaluate the source and fate of cysteine
- 16:12 – 16:39
- Thales Papagiannakopoulos (NYU Grossman School of Medicine)
- Uncovering metabolic bottlenecks in KRAS–driven lung cancer
- 16:39 – 17:06
- Brian Cunniff (University of Vermont Cancer Center) [Online]
- A redox–dependent cancer therapy targeting peroxiredoxin 3 being tested in phase 1/2 clinical trials
- 17:06 – 17:33
- Douglas D. Thomas (University of Illinois Chicago)
- Nitric oxide is a master regulator of the cellular methylome in cancer
- 17:33 – 18:00
- David Anderson Wink (National Cancer Institute)
- NOS2 and COX2 powerly shape the immune profile in estrogen negative breast cancer. A new target for immune Therapy
- 18:10 – 18:30
- Closing Remarks
- Motohiro Nishida (Kyushu University)
Medical Megabank
- Saturday, October 29, 2022
- Session N5: Arginine and Arginase – from Sickle Cell Disease to COVID
- Chairperson: Claudia R. Morris (Emory University School of Medicine; Children's Healthcare of Atlanta)
- 16:00 – 16:30
- Claudia R. Morris (Emory University)
- Clinical manifestations of an arginine deficiency syndrome
- 16:30 – 16:55
- Richard Onalo (University of Abuja)
- Arginine therapy in children with sickle cell vaso–occlusive painful episodes: Lessons from Nigeria
- 16:55 – 17:20
- Juan Bernardo Ochoa Gautier (Medical Director ICU – Hunterdon Medical Center) [Online]
- Treating arginine deficiency after trauma/surgery (physical injury)
- 17:20 – 17:35
- Augusto C. Ochoa (LSU–LCMC Cancer Center, NEW ORLEANS, School of Medicine) [Online]
- Severe COVID–19 an arginine depletion syndrome? Effects on immunity and arginine supplementation strategies
- 17:35 – 17:50
- Gaetano Santulli (Albert Einstein College of Medicine) [Online]
- Beneficial effects of L–arginine in COVID–19 patients: A randomized, double–blind, placebo–controlled, parallel–group trial
- 17:50 – 18:00
- Discussion
- Sunday, October 30, 2022
- Session N13: NO and Supersulfides in Signal Transduction
- Chairpersons:
Hiroaki Miki (Osaka University)
Yosuke Funato (Osaka University) - 16:00 – 16:24
- Hiroaki Miki (Osaka University)
- Regulation of oncogenic protein PRL by diverse chemical modifications of its active cysteine
- 16:24 – 16:48
- Yasuhito Onodera (Hokkaido University)
- Regulated spatial distribution of mitochondria reconciles invasiveness and redox homeostasis of cancer cells
- 16:48 – 17:12
- Atsushi Matsuzawa (Tohoku University)
- Regulatory mechanisms of the novel cell death parthanatos induced by ROS signaling
- 17:12 – 17:36
- Adam Carl Straub (University of Pittsburgh)
- Cytochrome b5 reductase 3 and cGMP signaling in cardiovascular disease and stroke
- 17:36 – 18:00
- Péter Nagy (National Institute of Oncology) [online]
- Reprogrammed transsulfuration promotes tumor progression via tumor specific mechanisms
IDAC
- Saturday, October 29, 2022
- Session N3: NO and Supersulfides in Inflammation and Aging
- Chairpersons:
Tomohiro Sawa (Kumamoto University)
Hasan Zaki (The University of Texas Southwestern Medical Center) - 10:00 – 10:28
- Hasan Zaki (The University of Texas Southwestern Medical Center)
- Interplay between diet, gut microbiota, and inflammatory Disorders
- 10:28 – 10:56
- Christopher M. Hine (Cleveland Clinic Lerner Research Institute) [Online]
- Maximized lifespan and healthspan extension via caloric restriction in mice is dependent on the H2S generating enzyme cystathionine γ–lyase
- 10:56 – 11:24
- Yvonne Janssen–Heininger (University of Vermont) [Online]
- Glutaredoxin–mediated control of glutathione through metabolic reprogramming
- 11:24 – 11:42
- Tadahisa Numakura (Tohoku University)
- Reactive persulfide species in chronic respiratory diseases: Potential roles in airway protection, TCR signaling and allergic inflammation
- 11:42 – 12:00
- Tomohiro Sawa (Kumamoto University)
- Regulation of innate immune responses by reactive sulfur species
- Sunday, October 30, 2022
- Session N14 (YIS): Rising Star Session
- Chairpersons:
Douglas Thomas (University of Illinois at Chicago)
Sruti Shiva (University of Pittsburgh School of Medicine) - 16:00 – 16:20
- Christopher Switzer (Queen Mary University of London)
- Nitric oxide and DNA methylation: Epigenetic mechanisms of tumorigenesis
- 16:20 – 16:40
- Sophia Katharina Heuser (Heinrich–Heine–University)
- Erythroid specific knock out of soluble guanylate cyclase leads to disrupted erythropoiesis, anemia and splenomegaly
- 16:40 – 17:00
- Anthony William Demartino (University of Maryland School of Medicine)
- Thiol facilitated reductive nitrosylation reaction of NO and ferric heme form a labile iron–nitrosyl–heme and thiyl radical
- 17:00 – 17:20
- Tejaswini Parlapalle Reddy (Houston Methodist Research Institute)
- NOS inhibition reverses epithelial–to–mesenchymal transition and synergizes with alpelisib in metaplastic breast cancer
- 17:20 – 17:40
- Mabruka Alfaidi (LSU Health Shreveport) [Online]
- Nck1 adaptor protein and vascular disease functions
- 17:40 – 18:00
- Lucas R. Carvalho (Karolinska Institutet) [Online]
- Effects of disturbed oral microbiota by chlorhexidine mouthwash on nitrate–nitrite–nitric oxide homeostasis and diet–induced obesity
*Check full program Redox Week in Sendai 2022
Contact
Email: international_no*grp.tohoku.ac.jp (change * to @)