International Symposium 2: in conjunction with International Persulfide Meeting
Information
Date
Monday, October 31, 2022
Venue
Hybrid: Campus Map of Seiryo Campus
- Seiryo Auditorium: School of Medicine Centennial Hall, Seiryo Campus, Tohoku University [Access]
- IDAC: Institute of Development, Aging and Cancer, Seiryo Campus, Tohoku University [Access]
- Gonryo Hall: Gonryo Hall, Seiryo Campus, Tohoku University [Access]
Invited Speakers
Keith Blackwell (Harvard University)
Neil John Bulleid (University of Glasgow)
Chuang–Rung Chang (National Tsing Hua University)
Sarin Chimnaronk (Mahidol University)
Marcus Conrad (Helmholtz Munich)
Deborah Fass (Weizmann Institute of Science)
Martin Feelisch (University of Southampton)
Milos R. Filipovic (Leibniz Institute for Analytical Sciences, ISAS, e.V.)
Jon M. Fukuto (Sonoma State University / Johns Hopkins University)
Christos Gatsogiannis (Universigy of Münster)
Adrian J. Hobbs (Queen Mary University of London)
Kenji Inaba (Tohoku University)
Shinpei Kawaoka (Tohoku University)
Chris Kevil (LSU Health Shreveport)
Myung–Shik Lee (Yonsei University)
David J. Lefer (Cedars–Sinai)
Yoichi Miyamoto (Showa University School of Dentistry)
Shohei Murakami (Tohoku University)
Osamu Nagano (Keio University)
Satoshi Ninagawa (Kobe University)
Yasumitsu Ogura (Chiba University)
Masaki Okumura (Tohoku University)
Kenneth R. Olson (Indiana University School of Medicine)
Rakesh P. Patel (University of Alabama Birmingham)
Bindu D. Paul (Johns Hopkins University)
Andrew A. Pieper (Case Western Reserve University)
Mike Pluth (University of Oregon)
Yoshiro Saito (Tohoku University)
Guenter Schwarz (University of Cologne)
Roberto Sitia (Università Vita–Salute San Raffaele Hospital)
Brent R. Stockwell (Columbia University)
Nobuaki Takahashi (Kyoto University)
Keiyo Takubo (Research Institute National Center for Global Health and Medicine)
Atsushi Tanaka (Yamagata University)
Takehiko Tosha (RIKEN SPring–8)
Masaki Unno (Ibaraki University)
Masayuki Yamamoto (Tohoku University)
Shigeru Yanagi (Gakushuin University)
Time Schedule [Oct. 28, 2022 Updated]
* Please click to open details
Seiryo Auditorium
- 08:45 – 09:00
- Opening Remarks
- Motoko Kotani (Exective Vice President for Research, Tohoku University)
- Plenary Lecture
- Chairperson: Yoshiro Saito (Tohoku University)
- 09:00 – 09:45
- Masayuki Yamamoto (Tohoku University)
- Elucidation of molecular basis of oxidative stress response utilizing mouse, human and space biology
- Session T1: Metabolism of Metal, Sulfur and Selenium in Redox Biology and Medicine
- Chairpersons:
Yoshiro Saito (Tohoku University)
Yasumitsu Ogura (Chiba University) - 10:00 – 10:30
- Brent R. Stockwell (Columbia University) [Online]
- 10 years of ferroptosis: New mechanisms and therapeutic applications
- 10:30 – 11:00
- Marcus Conrad (Helmholtz Munich)
- Ferroptosis: From basic mechanisms to therapeutic opportunities
- 11:00 – 11:20
- Yoshiro Saito (Tohoku University)
- Selenoprotein P as a critical regulator of selenium metabolism– Implication to iron metabolism
- 11:20 – 11:40
- Yasumitsu Ogura (Chiba University)
- Metabolism of selenium for urinary excretion
- 11:40 – 12:00
- Nobuaki Takahashi (Kyoto University)
- Oxidative stress defense in cancer
- Session S1: Sulfur and Oxygen Redox Biology and Medicine
- Chairpersons:
Chris Kevil (LSU Health Shreveport)
Péter Nagy (National Institute of Oncology) - 13:00 – 13:30
- Rakesh P. Patel (University of Alabama at Birmingham)
- Redox regulation of N–glycans: Implications for red and vascular cell inflammation
- 13:30 – 14:00
- Chris Kevil (LSU Health Shreveport)
- Tissue specific roles of cystathionine gamma lyase in regulating vascular function and growth
- 14:00 – 14:30
- Martin Feelisch (University of Southampton)
- Stress signalling and redox balance – From origin of life chemistry to where we are now
- 14:30 – 15:00
- David J. Lefer (Cedars–Sinai)
- H2S therapy improves diastolic dysfunction and exercise capacity in heart failure with preserved ejection fraction
- 15:00 – 15:30
- Bindu D. Paul (Johns Hopkins University)
- Protective roles of hydrogen sulfide in neurodegenerative diseases
- Session S2: Redox Biology in Reactive Sulfur, Oxygen, and Chalcogens
- Chairpersons:
Jon M. Fukuto (Sonoma State University / Johns Hopkins University)
Ming Xian (Brown University) - 15:40 – 16:10
- Jon M. Fukuto (Sonoma State University / Johns Hopkins University)
- The chemical biology of hydropersulfides and related species
- 16:10 – 16:25
- Adrian J. Hobbs (Queen Mary University of London)
- Vasorelaxant properties of hydropersulfides: Interaction with S–nitrosothiols
- 16:25 – 16:55
- Milos R. Filipovic (Leibniz Institute for Analytical Sciences, ISAS, e.V.)
- Age–induced persulfide remodelling predisposes brain for neurodegenerative diseases
- 16:55 – 17:25
- Mike Pluth (University of Oregon) [Online]
- New approaches to investigate small molecule reactive sulfur species and related compounds
- 17:25 – 17:55
- Kenneth R. Olson (Indiana University School of Medicine)
- Sulfur metabolism by antioxidant nutraceuticals and related compounds: An alternative pathway to redox homeostasis
- 17:55 – 18:25
- Guenter Schwarz (University of Cologne)
- Sulfite oxidase in health and disease: The intimate interplay between sulfite and hydrogen sulfide
- 18:25 – 18:40
- Yoichi Miyamoto (Showa University School of Dentistry)
- The roles of sulfides in bone resorption
IDAC
- Session S3: Supersulfide in Development and Aging
- Chairpersons:
Shinpei Kawaoka (Tohoku University)
Andrew Pieper (Case Western Reserve University) - 13:00 – 13:23
- Shohei Murakami (Tohoku University)
- Physiological function of mitochondrial sulfur metabolism in hematopoietic stem cells
- 13:23 – 13:46
- Keiyo Takubo (Research Institute National Center for Global Health and Medicine)
- Metabolic resilience common to stem cells in aging hematopoiesis and leukemia
- 13:46 – 14:15
- Keith Blackwell (Harvard University)
- Redox regulation in stress resistance, metabolic homeostasis, and longevity
- 14:15 – 14:38
- Osamu Nagano (Keio University)
- Novel approach for cancer therapy by simultaneous targeting of xCT–dependent cystine transport and aldehyde dehydrogenase activity
- 14:38 – 15:01
- Shinpei Kawaoka (Tohoku University)
- Enhancer regulation of hepatic aerobic respiration
- 15:01 – 15:30
- Andrew A. Pieper (Case Western Reserve University)
- Discovery of an NAD+–stabilizing agent with protective efficacy in neurodegenerative disease
- Session T5: Mitochondria Biology and Human Disease I
- Chairpersons:
Shigeru Yanagi (Gakushuin University)
Atsushi Tanaka (Yamagata University) - 15:40 – 16:09
- Chuang–Rung Chang (National Tsing Hua University)
- Characterizing the correlation of mitochondria dynamics and oxidative stress
- 16:09 – 16:38
- Atsushi Tanaka (Yamagata University)
- Mitochondrial ferritin functions as a beacon for sensing mitochondrial integrity and cellular iron metabolism
- 16:38 – 17:07
- Shigeru Yanagi (Gakushuin University)
- Iron metabolism in the ER–mitochondrial contact site regulated by redox condition
- 17:07 – 17:36
- Myung–Shik Lee (Yonsei University)
- Mitochondrial event as an ultimate step in ferroptosis
Gonryo Hall
- Session T4: Protein Quality Control through Redox Regulation
- Chairperson: Ryo Ushioda (Kyoto Sangyo University)
- 13:00 – 13:25
- Kenji Inaba (Tohoku University)
- Molecular basis of redox– and zinc–dependent protein quality control at the ER–Golgi interface
- Kenji Inaba (Tohoku University)
- 13:25 – 13:42
- Satoshi Ninagawa (Kobe University)
- EDEM2 forms a stable disulfide bond with TXNDC11 in the endoplasmic reticulum and exerts enzymatic activity
- Satoshi Ninagawa (Kobe University)
- 13:42 – 14:12
- Deborah Fass (Weizmann Institute of Science)
- Redox regulation of Golgi glycosyltransferases by the enzyme QSOX1 maintains the gut mucosal barrier
- Deborah Fass (Weizmann Institute of Science)
- 14:12 – 14:42
- Neil John Bulleid (University of Glasgow)
- Structural and functional characterisation of ER–localised methionine sulfoxide reductase
- Neil John Bulleid (University of Glasgow)
- 14:42 – 14:59
- Masaki Okumura (Tohoku University)
- Protein disulfide isomerase family; their molecular actions and functions
- Masaki Okumura (Tohoku University)
- 14:59 – 15:29
- Roberto Sitia (Università Vita–Salute San Raffaele Hospital)
- Multistep redox quality control in the biogenesis of complex secretory proteins
- Roberto Sitia (Università Vita–Salute San Raffaele Hospital)
- Session T3: Structural Biology for Deciphering Supersulfides Function
- Chairpersons:
Kei Wada (University of Miyazaki)
Yoshikazu Tanaka (Tohoku University) - 15:40 – 16:10
- Sarin Chimnaronk (Mahidol University) [Online]
- A collaborative study on the discovery of novel chemotypes against dengue RNA polymerase
- Sarin Chimnaronk (Mahidol University) [Online]
- 16:10 – 16:40
- Takehiko Tosha (RIKEN SPring–8)
- Mechanism of biological nitric oxide reduction proved by time–resolved structural analysis
- Takehiko Tosha (RIKEN SPring–8)
- 16:40 – 17:10
- Masaki Unno (Ibaraki University)
- Neutron structural analysis and computational chemistry reveal the control mechanism of the redox potential of 4Fe–4S type ferredoxin from Bacillus thermoproteolyticus
- Masaki Unno (Ibaraki University)
- 17:10 – 17:40
- Christos Gatsogiannis (Universigy of Münster) [Online]
- Good things come to those who bait: structural insights into peroxisomal receptor import and recycling
- Christos Gatsogiannis (Universigy of Münster) [Online]
*Check full program Redox Week in Sendai 2022
Contact
Email: international_no*grp.tohoku.ac.jp (change * to @)