International Symposium: The Environmental Response Ⅵ

Environmental Stress Response and Survival Strategy of Human Being

International Symposium: The Environmental Response Ⅵ

Information

We have been organizing a series of “The Environmental Response Symposium”, focused on the KEAP1–NRF2 system, in Japan once every few years. It has been 3 years since the last Environmental Response V Symposium. In the intervening period, we have seen many interesting developments in the KEAP1–NRF2 field. The purpose of the symposium is to exchange and discuss the most recent cutting–edge research in the field of KEAP1 and NRF2.

Date

Friday, November 3, 2023 – Sunday, November 5, 2023

Venue

School of Medicine Centennial Hall (Seiryo Auditorium), Seiryo Campus, Tohoku University [Access]

Invited Speakers

Elias S. J. Arnér (Karolinska Institutet)
Amedeo Columbano (University of Cagliari)
Ian M. Copple (University of Liverpool)
Antonio Cuadrado (Autonomous University of Madrid)
Gina M. DeNicola (Moffitt Cancer Center)
Albena T. Dinkova–Kostova (University of Dundee)
John D. Hayes (University of Dundee)
Tetsuro Ishii (University of Tsukuba)
Ken Itoh (Hirosaki University)
Youngtae Jeong (Daegu Gyeongbuk Institute of Science and Technology (DGIST))
Thomas W. Kensler (Fred Hutchinson Cancer Research Center)
Akira Kobayashi (Doshisha University)
Mi–Kyoung Kwak (The Catholic University of Korea)
Anna–Liisa Levonen (University of Eastern Finland)
Karen T. Liby (Indiana University)
Michael B. Major (Washington University in St. Louis)
Terry W. Moore (University of Illinois at Chicago)
Hozumi Motohashi (Tohoku University)
David Olagnier (Aarhus University)
Thales Papagiannakopoulos (NYU Medical School)
Jingbo Pi (China Medical University)
Ana I. Rojo (Universidad Autónoma de Madrid)
Young–Joon Surh (Seoul National University)
Kate Sutherland (The Walter and Eliza Hall Institute of Medical Research)
Gerasimos P. Sykiotis (Université de Lausanne)
Masayuki Yamamoto (Tohoku University)
Donna D. Zhang (The University of Arizona)

Registration

Registration deadline: Tuesday, October 10, 2023, 24:00 (JST)
– Closed

Time Schedule

Friday, November 3, 2023: 09:30 – 09:35; Opening Remark; Masayuki Yamamoto (Tohoku University)

1) Keynote Lectures Co–sponsored by Chugai Pharmaceutical Co., Ltd.
Chairpersons: Masayuki Yamamoto (Tohoku University) Thomas W. Kensler (Fred Hutchinson Cancer Research Center): 09:35 – 10:20; Masayuki Yamamoto (Tohoku University); Sixth Environmental Stress Symposium on the KEAP1–NRF2 System Regulating the Molecular Basis of Oxidative Stress Response and Its Perturbation

10:20 – 11:05

Thomas W. Kensler (Fred Hutchinson Cancer Research Center)

How Important is NRF2 for the Pharmacodynamic Action of “NRF2 Inducers”?

11:05 – 11:25

Break

2) Session: Molecular Mechanisms of the KEAP1–NRF2 System Function
Chairperson: Donna D. Zhang (University of Arizona): 11:25 – 11:55; Hozumi Motohashi (Tohoku University); NRF2 Buddy for Transcriptional Activation

11:55 – 12:25

Michael B. Major (Washington University in St. Louis)

Proximity Proteomic Analysis Reveals Mechanisms of KEAP1 Inactivation by Cysteine Modification and New Connections for NRF2 in Parkinson's Disease

12:25 – 13:55

Lunch time & Poster Discussion (ODD number)

2) Session: Molecular Mechanisms of the KEAP1–NRF2 System Function
Chairperson: Donna D. Zhang (University of Arizona): 13:55 – 14:35; Albena T. Dinkova–Kostova (University of Dundee); Nrf2 depletion in the context of Keap1 loss–of–function leads to mitolysosome accumulation

14:35 – 15:05

Ken Itoh (Hirosaki University)

Cross–talk of GCN1–GCN2 branch of ISR and Nrf2 pathway in environmental stress response

15:05 – 15:35

Elias S. J. Arnér (Karolinska Institutet)

Selenium in control of ferroptosis – potential roles and cross–talk between glutathione peroxidases and thioredoxin reductases

15:35 – 16:05

Takafumi Suzuki (Tohoku University)

Molecular Basis of Stress Response by the KEAP1–NRF2 System

16:05 – 16:25

Break

2) Session: Molecular Mechanisms of the KEAP1–NRF2 System Function
Chairperson: Ken Itoh (Hirosaki University): 16:25 – 16:55; Donna D. Zhang (University of Arizona); From Antioxidant Defense to Iron Homeostasis: NRF2's Multifaceted Guard Against Ferroptosis

16:55 – 17:15

Tetsuro Ishii (Tsukuba University)

Mechanisms underlying Nrf2 activation by non–lethal levels of hydrogen peroxide: roles of glutathione sensor neutral sphingomyelinase2, p38 and ERK MAP kinases and prolyl cis/trans isomerase Pin1

17:15 – 17:35

John D. Hayes (University of Dundee)

Inhibition of liver fibrosis by Nrf2: antagonism of Nrf2 by TGF–beta

17:35 – 17:55

Nobunao Wakabayashi (Fred Hutchinson Cancer Center)

Forced Hepatic Expression of NRF2 or NQO1 Alleviates Hepatic Lipid Accumulation and Hepatocellular Damage in a Lipodystrophy Mouse Model

17:55 – 18:15

Youngtae Jeong (Daegu Gyeongbuk Institute of Science and Technology (DGIST))

Keap1–Nrf2 pathway in the cancer therapeutic resistance and anti–tumor immunity

18:30 –

Welcome Reception @Cafeteria

Saturday, November 4, 2023
3) Session: The KEAP1–NRF2 System and Cancers
Chairperson: Hozumi Motohashi (Tohoku University): 09:00 – 09:30; Anna–Liisa Levonen (University of Eastern Finland); NRF2 and Cancer Immunity

09:30 – 10:00

Young–Joon Surh (Seoul National University)

Pseudohypoxic stabilization of HIF–1α through direct interaction with NRF2 in hepatocellular carcinoma

10:00 – 10:30

Gina M. DeNicola (Moffitt Cancer Center)

Distinct Nrf2 signaling thresholds mediate lung tumor initiation and progression

10:30 – 11:00

Kate D. Sutherland (The Walter and Eliza Hall Institute of Medical Research)

Identifying novel vulnerabilities to sensitise KEAP1 mutant lung adenocarcinoma to T cell mediated killing

11:00 – 11:20

Break

3) Session: The KEAP1–NRF2 System and Cancers
Chairperson: Anna–Liisa Leveon (University of Eastern Finland): 11:20 – 11:40; Fumiki Katsuoka (Tohoku University); Functional Characterization of CNC–sMAF Heterodimers by the Tethered Dimer Rescue System

11:40 – 12:00

Liam Baird (Tohoku University)

Immunoediting of KEAP1–NRF2 mutant tumours is required to circumvent NRF2–mediated immune surveillance

12:00 – 12:30

Thales Papagiannakopoulos (NYU Medical School)

Uncovering Metabolic Bottlenecks in KEAP1–mutant Lung Cancer

12:30 – 12:50

Akira Kobayashi (Doshisha University)

NRF3: The NRF2–Related Transcription Factor Responding to Arginine Depletion in Cancer

12:50 – 14:20

Lunch time & Poster Discussion (EVEN number)

4) Session: The KEAP1–NRF2 System and Diseases
Chairperson: Keiko Taguchi (The University of Tokyo): 14:20 – 14:50; Jingbo Pi (China Medical University); NRF1 and NRF2 coordinate osteoclastogenesis and bone remodeling

14:50 – 15:20

Gerasimos P. Sykiotis (Université de Lausanne)

New roles of Keap1/Nrf2 signaling in thyroid gland function and thyroid pathophysiology

15:20 – 15:40

Mi–Kyoung Kwak (The Catholic University of Korea)

NRF2 and HIF–2α–induced cancer stem cell phenotypes in chronic hypoxic conditions

15:40 – 16:00

Break

4) Session: The KEAP1–NRF2 System and Diseases
Chairperson: John D. Hayes (University of Dundee): 16:00 – 16:30; Ian M. Copple (University of Liverpool); Pharmacology & toxicology of Nrf2 in the liver

16:30 – 16:50

Ana I. Rojo (Universidad Autónoma de Madrid)

Defining the role of the NRF2 transcription factor in synaptic maintenance in Alzheimer's disease

16:50 – 17:10

Ioannis Trougakos (University of Athens)

NRF2 in stress, ageing and disease

17:10 – 17:30

Florian A. Karreth (Moffitt Cancer Center)

The small MAF transcription factor MAFG is a potent driver of melanoma

17:30 – 17:50

Masaki Hoshino (Chugai Pharmaceutical Co., Ltd.)

The efficacy of the novel NRF2 activator CH0924 for acute kidney injury

18:15 –

Round–Table Discussion @ToMMo atrium

Sunday, November 5, 2023
5) Session: The KEAP1–NRF2 System and Drug Development
Chairperson: Antonio Cuadrado (Autonomous University of Madrid): 08:40 – 09:20; Karen T. Liby (Indiana University) Co–sponsored by Kyowa Kirin Co.,Ltd.; Developing therapies to target NRF2

09:20 – 09:50

Terry W. Moore (University of Illinois at Chicago)

Non–Electrophilic NRF2 Activators Promote Wound Healing in Human Keratinocytes and Diabetic Mice and Demonstrate Selective Downstream Gene Targeting

09:50 – 10:10

Akihito Otsuki (Tohoku University)

ibSLS database: an integrated database for the exploration of environmental stress response during space flight

10:10 – 10:30

Break

5) Session: The KEAP1–NRF2 System and Drug Development
Chairperson: Albena T. Dinkova–Kostova (University of Dundee): 10:30 – 10:45; Anqi Zhang (Tohoku University); Nrf2 Activation Improves Experimental Rheumatoid Arthritis

10:45 – 11:00

Sharadha Dayalan Naidu (University of Dundee)

Pharmacologic and genetic activation of Nrf2 confers anti–fibrotic effects

11:00 – 11:15

Aikseng Ooi (University of Arizona)

Sexual dimorphism of NRF2 target gene modulation

11:15 – 11:30

Xiaoxin Luke Chen (Coriell Institute for Medical Research)

Small Molecule Screen Identifies Pyrimethamine as an Inhibitor of NRF2–driven Esophageal Hyperplasia

11:30 – 12:00

Antonio Cuadrado (Autonomous University of Madrid)

Targeting the NRF2/beta–TrCP axis in liver disease

12:00 – 12:15

Closing Remark

Masayuki Yamamoto (Tohoku University)

12:15 – 13:30

Lunch

16:00 –

Excursion see more details

Elected Poster Presenters

Liam Baird (Tohoku University)
Xiaoxin Luke Chen (Coriell Institute for Medical Research)
Masaki Hoshino (Chugai Pharmaceutical Co., Ltd.)
Florian A. Karreth (Moffitt Cancer Center)
Fumiki Katsuoka (Tohoku University)
Sharadha Dayalan Naidu (Affiliation)
Aikseng Ooi (University of Arizona)
Akihito Otsuki (Tohoku University)
Takafumi Suzuki (Tohoku University)
Ioannis Trougakos (University of Athens)
Nobunao Wakabayashi (Fred Hutchinson Cancer Center)
Anqi Zhang (Tohoku University)